Abstract:At present, China has made great achievements in the construction of major scientific and technological infrastructure. However, there is still a certain gap with the world-class infrastructure in operation management. The operation efficiency, whole process management method in the operation stage, and the post-evaluation management need to be further improved and optimized. In the "National Major Science and Technology Infrastructure Construction Medium and Long-term Plan (2012-2030)" issued by the State Council, it is clearly proposed to improve the management system of the national major scientific and technological infrastructures, including to standardize and promote the construction, optimize the operation and management, formulate management methods that conform to the characteristics and development laws of infrastructures, strengthen the operation evaluation, and improve the operation efficiency of major scientific and technological infrastructures. Thus, further research on the constructive strategies for scientific and efficient operation management based on the practical experiences is of great significance. The Institute of Plasma Physics of Hefei Institute of Physical Science, Chinese Academy of Sciences (ASIPP) has built China's first regular Superconducting Tokamak (HT-7) and the world's first non-circular Experimental Advanced Superconducting Tokamak (EAST). To improve the management of EAST continually, this paper analyzes the exploration and innovation practice of the EAST from three aspects: top-level design, experimental organization, and evaluation. The three-level management system has been established from the leadership, the physics and experimental operation department (PEOP) to the first-level system, so as to implement unified plan and hierarchical management for promoting the outputs. In accordance with the management theory of "Plan-Do-Check-Act", the whole process management mechanism covering the EAST operation cycle has been formed. Specially, the medium- and long-term plans of EAST is formulated via domestic evaluation and international evaluation and the PEOP is responsible for leading the EAST operation plan and target formulation. Based on the composition of facilities and combined with the operation needs, the ASIPP set up a first-level system and used young backbone as the person in charge, decomposing tasks and clarifying responsibilities. The evaluation of EAST operation has been strengthened, and a series of improvement measures such as optimizing the organization and management of basic research and innovating international cooperation models have been applied. According to the experience of the EAST, countermeasures and suggestions for the management and development of national major scientific and technological infrastructures were provided, such as optimizing the scientific research organization model, improving management methods, strengthening team building, enhancing worldwide openness and cooperation.