Abstract:[Purpose/Significance] Mastering key core technologies means mastering the initiative of innovation and development, at present, China is still in the stage of key core technologies being subject to people, this paper will identify the important influencing factors of key core technology research, and analyze the types of factors. [Approach/Methodology] In this paper, the grounded theory method is used to extract the key core technical factors and construct the model of the key core technology research factors, the DEMEL method is used to analyze the important influencing factors, and the ISM method is used to analyze the action types of important influencing factors. [Results/Conclusions] This paper finally concludes nine important influencing factors of key core technology research, such as national laboratory, policy, fund, and strategic scientist, divides the above nine influencing factors into direct factors, indirect factors and fundamental factors of key core technology research, and puts forward four suggestions, including the independent training and introduction of scientific and technological leaders.