Abstract:This article is based on panel data of 284 prefecture-level cities in China from 1991 to 2020, and establishes a spatial panel double difference model to study the impact of the Belt and Road Initiative on innovation efficiency and its spillover effects. The main conclusions of the article are as follows: (1) The Belt and Road Initiative can significantly improve the innovation efficiency of node cities, and the driving effect of the initiative on innovation in node cities is significant until 2020. (2) The Belt and Road Initiative has a significant spillover effect on the improvement of innovation efficiency in cities within 100 kilometers of node cities, and there is a distance decay effect. (3) The impact of the Belt and Road Initiative on innovation efficiency is partly achieved by improving the level of foreign trade. (4) The impact of the Belt and Road Initiative on innovation varies in different regions. From the perspective of direct effects, the impact of the initiative is positive in all three regions, and the largest in the western region and the smallest in the eastern region; from the perspective of spillover effects, the spillover effect of the initiative is negative in the western region, and positive in both eastern and central regions. Based on these conclusions, the article puts forward some policy suggestions.