Abstract:Science and technology support is an important engine to deal with public health emergencies. How to improve emergency management ability through the construction of science and technology support system is an important issue to be solved urgently. Starting from the framework of "technology-organization-environment", based on the necessary condition analysis and fuzzy set qualitative comparative analysis, the influence mechanism of science and technology support on the handling level of public health emergencies in China was explored. It is found that biomedical innovation, digital technology innovation, monitoring and early warning ability, and industrial environment for the transformation of results are the necessary conditions to affect the handling level of public health emergencies. There are four driving paths in the configuration of high handling level of public health emergencies, namely science-policy-driven, digital innovation-driven, institutional innovation-driven and early-warning driven. These driving paths contribute to the response to public health emergencies, protect public health, promote social stability, and thus promote the new development of "healthy China".