Abstract:The evolution of scientific technological innovation system and knowledge production mode shall promote the paradigm transition of university governance. At present, the new patterns of domestic and international dual circulation, high-quality development and education first have made the construction of entrepreneurial universities in the new era an inevitable trend. Pointing the foundation and the conflicts of high education system, the development of scientific technological innovation in the context of entrepreneurial universities was analyzed by multi-dimensional perspectives, including horizontally balancing the varsity spirit, the management value and the national strategies, while vertically combining the theoretical models, the national policies and the transformation practices. The main line running through their innovation governance is the logical unity of the multi-mode knowledge, the multi-faceted cultivation and the diversified organizations. This paper focus on deconstructing the macro-, meso-, microscopic as well as the epitaxial bulks participated in the co-governance of the entrepreneurial university ecosystem, and clarifying the responsibilities assigned by their own roles. The science and technology union give full play to its momentum advantages and enhance the system efficiency cohesively, aiming to explore the fully chain coupled innovation governance of universities toward Chinese modernization.