Abstract:Regional innovation is an important driving force for China's economic and social development and the enhancement of new quality productivity. As the core driving force in regional innovation, how to synergize the knowledge subjects and discern the path of innovation contribution is the key to improve China's innovation level and enhance China's innovation capability. To this end, on the basis of case study and process tracking, 29 inter-provincial regional knowledge subject combinations and time evolution are analyzed using FsQCA and dynamic qualitative comparative analysis methods. The analysis results show that the balanced knowledge subject contribution of the multiple synergistic governance type is a relatively reasonable grouping to promote regional innovation development, while during the period of 2004-2019, there are elemental fluctuations in the innovation contribution of China's knowledge subjects, and there is an imbalance in the grouping contribution in different time periods, and the theoretical market-driven type dominated by the enterprise knowledge subjects presents a "dominant trajectory The theoretical market-driven type dominated by enterprise knowledge subjects presents a "dominant trajectory", and the basic R&D pillar type dominated by university knowledge subjects presents a "buffer dominant trajectory", and both of them have long been occupying an important position in innovation contribution; meanwhile, the structure of knowledge subjects' contribution is more solid and concentrated, but gradually presents a scattering trend; therefore, it is necessary to customize according to regional realities, and effectively play the role of innovation contribution based on a sound innovation environment in order to improve the innovation environment. Therefore, it is necessary to adapt to regional realities and effectively utilize the combined effectiveness of knowledge subjects on the basis of a sound innovation environment, so as to promote the enhancement and development of regional innovation.