Abstract:"Innovative mission" is one of the two fundamental tasks of higher education in China and a key task in promoting the modernization of Chinese style higher education. By focusing on 105 research teams from 28 science and engineering universities in China, this paper discusses the deep impact of team innovation mission on the innovation efficiency of university research teams, known as the "black box". The results show that the team innovation mission will promote the steady improvement of innovation efficiency in university research teams by forming a positive motivation for team promoting regulatory focus, thereby achieving high-quality innovation in science and engineering universities; And transformational leadership can significantly promote this effect. Therefore, it is recommended that relevant universities should not only actively promote and promote the "innovation mission", but also pay attention to the embedding and transformation mechanisms of team innovation missions, establish a "correct" value concept for university research team work, form a "positive energy" team work motivation, and build an efficient team innovation ecosystem.