Abstract:Based on the provincial panel data of China from 2011 to 2021, this paper constructs two kinds of spatial weight matrices and uses the dynamic spatial econometric analysis model to empirically discuss the different impacts of two innovation activities on economic development under the influence of high-tech industry the science and technology intensity and technology marketization level, and further comparatively analyzes the internal relationship among high-tech industry technology marketization level, different innovation activities and regional economic development in different regions. The empirical results show that: (1) The positive effect of independent R&D innovation on economic development is stronger in the long run, and the positive effect of the introduction of transnational innovation on economic development is stronger in the short run. (2) The science and technology intensity of high-tech industries has a significant positive moderating effect on the relationship between independent R&D innovation/transnational innovation introduction and economic development in that region, and it has a lasting effect. (3) With the improvement of the level of technology marketization in high-tech industries, the positive relationship between independent R&D innovation/ the introduction of transnational innovation on regional economic development has a nonlinear change of first decreasing and then increasing /first increasing and then decreasing, but the overall strength of this positive effect shows a weakening trend. (4) In sci-tech intensive/ less-intensive areas, with the change of technological marketization level of high-tech industry, the nonlinear influence of different innovation activities on regional economic development is the same, but the overall strength of effect is different.