Abstract:Based on a comprehensive perspective, this study takes 30 provinces and cities in China as its research subjects, employing the fuzzy set qualitative comparative analysis (fsQCA) method to explore diverse paths driving regional scientific and technological innovation. The research findings indicate that, firstly, individual factors do not constitute necessary conditions for high innovation performance in regional science and technology, high innovation performance results from the combined effects of multiple factors. Secondly, there are seven configurational paths driving high innovation performance, while two paths lead to non-high innovation performance, exhibiting a causal asymmetry between the two. Lastly, under specific circumstances, there exists a certain degree of substitutability between different configurational conditions. By integrating multiple levels of factors, identifying seven driving paths for high innovation performance in regional science and technology, the study provides a theoretical reference for provinces and cities to formulate differentiated strategies for enhancing scientific and technological innovation performance based on their own circumstances.