Abstract:Aiming at the problems of insufficient R&D investment and financial constraints in the early stage of radical innovation, this paper analyzes the impact of capital support mechanism and financial institutions" incentive and punishment mechanism on the cooperative R&D behavior of government, enterprises, universities, and research on radical innovation by using the evolutionary game method, and uses the Matlab software to carry out numerical simulation, to explore the influencing factors of deciding the strategy selection of the main body of the game in the cooperative R&D process. The study shows that:Enterprises and universities and research parties are more influenced by each other"s willingness to cooperate than the role of government guidance;Enterprises are more sensitive to the capital support mechanism, and excessive financial support reduces the necessity of government supervision, and the incentive mechanism of financial institutions has a greater impact on government-industry-academia-research cooperative R&D than the punishment mechanism;When financial institutions are not involved, although the influence effect of the government reward and punishment mechanism has a lag in the time dimension, the incentive policy and appropriate punishment can still effectively promote the active participation of industry-academia-research in cooperative R&D, and the government reward and punishment mechanism has a greater impact on the academia-research side;Enterprises are more sensitive to the perception of cost and benefit distribution ratio.