Abstract:The goal of the digital entrepreneurship ecosystem is to fully tap the entrepreneurial potential and stimulate entrepreneurial vitality and power. Based on the configuration perspective, combining the two methods of necessary condition analysis and fuzzy set qualitative comparative analysis, this paper uses the entrepreneurial ecosystem theory and takes the case data of 206 cities in China as samples, to explore the complex causal relationship between the financial capital, human capital, government expenditure scale, entrepreneurial culture, market size and digital technology in the system and the quality and efficiency level of urban entrepreneurship. It is found that single factor does not constitute the necessary condition for high entrepreneurial quality and efficiency. There are three paths to produce high entrepreneurial quality and efficiency, which are respectively driven by market and technology, driven by culture and capital under the dual dominance of digital technology and market, and driven by technology and finance under the logic of culture. All of above paths contain digital technology elements, highlighting its pivotal role in enhancing entrepreneurial quality and efficiency. There are two main types of paths that generate non-high levels of entrepreneurial quality and efficiency, and they have a causal asymmetric relationship with the paths that lead to high levels of entrepreneurial quality and efficiency. As multiple factors can achieve high regional entrepreneurial quality and efficiency in different ways, local governments should choose promotion strategies adapted to local development characteristics according to their own advantages, and concentrate resources to promote the development of key factors.