Abstract:The financial crisis in 2008 exposed the industry hollowing, then the American government began to promote the re-industrialization strategy. One of the important plans was "Made USA", which focused on bridging the gap between basic technology research and practical application. In order to ensure the smooth implementation of the plan, the US government has established a systematic management framework. The management me-chanism can provide useful inspiration for China's construction of powerful manufacturing co-untry. In terms of organizational management, the program has formed a four-level man-agement structure from top to bottom to ensure the effective implementation of national strategic goals. In terms of performance management, the manufacturing innovation institutes should provide regular reports to its funding agency and Manufacturing USA is mandated to provide an Annual Report to Congress. The Government Accountability Office is responsible for assessing the Manufacturing USA progam, sometimes third-party organizationswill also evaluate the plan.In terms of enforcement management the "Manufacturing USA"Program has the characteristics of whole-government, national participation and emphasis on the construction of an innovation ecosystem. Drawing on the experience of the United States, the construction of China's manufacturing innovation center needs to improve organizational management, optimize performance evaluation mechanisms and enforcement management.