Abstract:Singapore stands as a crucial innovation-driven economy in Asia, and a representative country in terms of the innovation system development. This research adapted the social process research methodology and historical institutionalism analytical framework to explore the formation and evolution of Singapore"s science, technology, and innovation (STI) system. The study revealed that crisis awareness played an initial factor that promoted Singapore to make a series of adjustments to its economic development model and choose to transform into an innovation-driven economy. Singapore has formed a government-led technological innovation system construction path. The key strategies encompass continuous policy development, dynamic adjustments in management organizations, comprehensive financial support throughout the entire process, the establishment of physical frameworks, and prioritizing the accumulation of talent reserves. Drawing inspiration from Singapore"s experience, in the process of building the STI system, China could leverage the force of government. By activating financial strategies and building a reliable network of dependencies, China could gradually realize the progressive effects of STI system development.