Abstract:With the rapid development of science and technology and the deepening of global cooperation, efficient and intelligent national laboratory management systems have become crucial for promoting scientific innovation and facilitating the sharing of research outcomes. This study aims to explore methodologies and strategies for constructing integrated management systems for national laboratories and their open sharing mechanisms. Through systematic analysis of existing international laboratory management models, key issues in current management systems are identified, including inefficient resource allocation, inadequate data sharing mechanisms, and slow transformation of innovative achievements. Subsequently, an integrated management system incorporating cutting-edge information technologies is proposed, which implements permission control based on a zero-trust security model, a data exchange platform supported by blockchain technology, and networked device management enabled by edge computing. The system demonstrates application cases of advanced equipment integration and open data platforms in shared resource management, while showcasing the effectiveness of cross-departmental resource sharing platforms in data openness and collaborative innovation. Research findings indicate that the comprehensive management system can provide strong support for scientific innovation by improving laboratory resource utilization efficiency, promoting scientific research collaboration, and standardizing laboratory management processes, achieving a transformation from "single function" to "comprehensive intelligence" in management models