Abstract:An efficient and healthy innovation ecosystem is an important guarantee and way for Guangzhou to build a demonstration base for mass entrepreneurship and innovation. By structuring an innovation ecosystem model, this paper analyzes the development status of Guangzhou"s innovation ecosystem from the perspective of Guangdong-Hong Kong-Macao Greater Bay Area, and finds that there are some problems in the current innovation ecosystem of Guangzhou, such as incomplete coordination system of innovation resources, inadequacy of the development of innovation platforms, infrequence of the interaction and exchange of innovation entities, weakness of the supporting role of innovation environment, and lower level of the international cooperation and innovation. So this paper suggests that: First, the government should introduce more targeted and effective policies to optimize the policy environment for collaborative innovation. Second, vigorously develop big data and artificial intelligence industries to improve the quality of innovation platforms; Third, build an innovation platform public service system to promote the coordinated development of innovation; Fourth, improve infrastructure construction to provide ecological and environmental support for collaborative innovation; Fifth, promote independence, learning and introduction, and create a new ecology for international innovation cooperation.