Abstract:Collaborative innovation is an effective way to improve the performance of industrial innovation. This article takes the pharmaceutical manufacturing industry as the research object. Using the fsQCA method, starting from the three levels of government, industry, universities, and research institutions, it analyzes the key factors and condition combinations of the triple helix collaborative innovation system driving industrial innovation performance, providing a path reference for regions with different resource conditions to generate high industrial innovation performance. The research results indicate that: (1) Having a professional foundation in universities is a necessary condition for high industrial innovation performance, and the core condition of high industrial technological innovation is included in the equivalent path of generating high innovation performance. (2) There are four paths to achieve high industrial innovation performance, which can be summarized in this article as three driving models: "industry academia collaborative driving" "industry led compensation", and "official industry academia cooperative development". (3) The driving path of "industry academia collaborative driving" indicates that, in the case of a relatively complete industry academia foundation, active government policy release can form high innovation performance; If there is a certain lack of government economic support, it can also promote the formation of high innovation performance in the pharmaceutical manufacturing industry. (4) The driving path of "industry driven compensation" indicates that strong industrial technological innovation and a solid foundation of university majors can compensate for the government"s lack of economic and policy support, thereby promoting the formation of high innovation performance in the pharmaceutical manufacturing industry. (5) The driving path of "government industry university cooperation development" indicates that not only does it have strong industrial and technological innovation capabilities, but also strong government economic support, strong investment in research institutions, and stable professional foundations in universities. The lack of investment in industrial research and development does not affect the formation of high innovation performance in the pharmaceutical manufacturing industry.