Abstract:Biological drugs are the main type of medication in national health insurance negotiations. National health insurance negotiations have had a significant impact on the innovation of biopharmaceutical companies. This paper takes China's biomedical A-share listed companies from 2014 to 2022 as a sample, and obtains relevant data through Guotaian database, to investigate the impact of the implementation of the medical insurance negotiation system on the innovation investment of biomedical enterprises. The results show that the implementation of the medical insurance negotiation system has significantly increased the innovation investment of biopharmaceutical enterprises. The mechanism test shows that the medical insurance negotiation policy promotes the increase of innovation investment of biopharmaceutical enterprises through two channels: "guidance effect" and "compensation effect". Further analysis shows that among non-state-owned enterprises and biomedical enterprises with strong intellectual property protection in their regions, the medical insurance negotiation policy has a more significant role in promoting the increase of enterprise innovation investment. Accordingly, it suggests including more medicines that meet the new healthcare needs of the public, have excellent clinical outcomes, and are of significant importance within the scope of national medical insurance negotiations; it also recommends formulating differentiated national medical insurance negotiation policies based on the heterogeneity of the pharmaceutical industry, regions, and levels of development.