Abstract:With the intensification of global competition and the rapid advancement of science and technology, enhancing regional innovation performance has become a critical driver for achieving sustainable economic development. Effective university-enterprise collaboration plays a pivotal role in fostering technological innovation and knowledge transfer. Exploring the key factors and their internal logic that affect regional innovation performance has important theoretical value and practical significance for optimizing innovation policies and enhancing regional competitiveness. In the relationship between the intensity of school-enterprise cooperation and regional innovation performance, its impact boundary also needs further study. Based on the theory of resource dependency and industry-university-research collaborative innovation theory, this study empirically investigates the impact of university-enterprise collaboration intensity on regional innovation performance. Using panel data from 26 provinces (autonomous regions, municipalities) in China from 2010 to 2019, this research constructs panel models, mediating effect models, moderating effect model and heterogeneity analysis. The empirical findings reveal three key insights: (1) University-industry collaboration intensity exhibits an inverted U-shaped effect on regional innovation performance, suggesting that while initial increases in collaboration drive innovation, excessive engagement may lead to diminishing returns; (2) Both university-led scientific and technological innovation and enterprise-driven technological advancements mediate the relationship between collaboration intensity and innovation outcomes, underscoring their complementary roles in regional development; (3) Regional type moderates these effects, indicating that geographical and economic contexts influence the efficacy of collaboration-driven innovation. (4) The impact of university-industry cooperation intensity on regional innovation performance shows differences under different scenarios of open economy and border effect. Based on this, it is proposed to promote the mobility of scientific and technological resources among different provinces, strengthen the linkage between various entities inside and outside the region, and reasonably control the intensity of university-industry cooperation.This research provides valuable insights for policymakers, emphasizing the need for tailored and region-specific innovation policies that optimize university-enterprise collaboration. By identifying the nonlinear effects and mediation pathways, this study offers practical guidance for regional governments and enterprises to refine their innovation strategies, ensuring more effective resource allocation and sustainable economic growth.