Abstract:With the increasing investment in science and technology projects, research on the effectiveness and optimization of government funding is becoming more and more important. In this paper, we take the field of artificial intelligence in the Natural Science Foundation of China (NSFC) as an example, and construct a multivariate heterogeneity framework of “scholar attributes-topic characteristics-funding modes”, and measure it by using the negative binomial regression model, multi-objective combinations, and non-dominated sorting genetic algorithms with elite strategies (NSGA-II). This paper identifies the influencing elements of multivariate heterogeneity and their influencing mechanisms, explores the optimal solution set that maximizes the performance of research output, and then explores the optimal strategy for talent cultivation-oriented-frontier-led differentiated goal selection. This paper provides quantitative and predictable references for the formulation of research management policies and the improvement strategies of funding policies, so as to promote scientific and technological progress.