Abstract:The advancement of modern technology has intensified the harm caused by serious scientific misconduct, making it a critical issue in research integrity governance. Grounded in Contingency Theory, System Analysis, and Interdisciplinary Research, this paper emphasizes that the core of serious misconduct lies in its consequences. It analyzes the governance landscape and identifies three major challenges: outdated concepts, incomplete targets, and unclear strategies. The analysis suggests combining Contingency Theory with a dual governance model: flexible organic governance in high-risk emerging fields, and structured mechanistic governance in low-risk, stable environments. This approach requires shifts in governance philosophy, targets, and methods, advocating situational adjustments, restrictive application of criminal law, and interdisciplinary coordination to protect both scientific freedom and public interest.