Abstract:This paper constructed policy document database, basing on 212 pieces of science and technology innovation policy in henan and guangdong province from 2005 to 2015 year, using the literature measurement analysis method, researching the evolution at different stage and itsdifferences of science and technologyinnovationpolicy in henan province and guangdong province by three aspects that the policy time distribution, department distribution and content distribution comparing. Draw lessons from policies of guangdong province related to science and technology innovation experience of developing and completing thelaws,regulations,on this basis, finally puts forward the proposals that highlight the characteristics, targeted, enforceability and strengthen connection of regional science and technology innovation policy in henan province.